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\u816b\u760d\u514d\u75ab\u3068\u306f<\/h1>\n

\"shuyoumenneki\"<\/a>\u5f53\u6559\u5ba4\u3067\u306f\u7814\u7a76\u306e\u5927\u304d\u306a\u67f1\u306e\u4e00\u3064\u3068\u3057\u3066\u3001\u816b\u760d\u514d\u75ab\u5206\u91ce\u306e\u7814\u7a76\u3092\u884c\u3063\u3066\u304a\u308a\u307e\u3059\u3002\u816b\u760d\u514d\u75ab\u5b66\u3068\u306f\u3001\u816b\u760d\u3001\u7279\u306b\u764c\uff08\u304c\u3093\uff09\u3068\u305d\u308c\u306b\u53cd\u5fdc\u3059\u308b\u4f53\u306e\u514d\u75ab\u80fd\u3068\u306e\u95a2\u4fc2\u3092\u7814\u7a76\u3057\u3001\u305d\u308c\u3092\u514d\u75ab\u7642\u6cd5\u30fb\u764c\u30ef\u30af\u30c1\u30f3\u7642\u6cd5\u306a\u3069\u306e\u764c\u306e\u6cbb\u7642\u306b\u5f79\u7acb\u3066\u308b\u3082\u306e\u3067\u3059\u3002\u624b\u8853\u30fb\u653e\u5c04\u7dda\u7167\u5c04\u30fb\u6297\u764c\u5264\u306b\u7d9a\u304f\u7b2c4\u306e\u764c\u6cbb\u7642\u306e\u624b\u6bb5\u3068\u3057\u3066\u3001\u307e\u305f\u6bd4\u8f03\u7684\u526f\u4f5c\u7528\u304c\u5c0f\u3055\u304f\u4f53\u3078\u306e\u8ca0\u62c5\u304c\u5c11\u306a\u3044\u6cbb\u7642\u3068\u3057\u3066\u3001\u305d\u306e\u7814\u7a76\u958b\u767a\u306b\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

 <\/p>\n

\u514d\u75ab\u7642\u6cd5\u7814\u7a76\u306e\u6b74\u53f2<\/h1>\n

19\u4e16\u7d00\u672b\u306b\u30a2\u30e1\u30ea\u30ab\u306e\u5916\u79d1\u533bColey\u306f\u6b7b\u3093\u3060\u7d30\u83cc\u3092\u764c\u60a3\u8005\u306b\u6ce8\u5c04\u3057\u3001\u5168\u8eab\u7684\u306b\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u306b\u3088\u308a\u3001\u764c\u7d44\u7e54\u304c\u6d88\u9000\u3059\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u305f\uff08Coley\u2019s toxin\uff09\u306e\u304c\u514d\u75ab\u7642\u6cd5\u306e\u59cb\u307e\u308a\u3067\u3057\u305f\u3002\u3055\u3089\u306b1980\u5e74\u4ee3\u306b\u306f\u30a2\u30e1\u30ea\u30ab\u306e\u56fd\u7acb\u764c\u7814\u7a76\u6240\u306e\u5916\u79d1\u90e8\u9577\u3067\u3001\u30ec\u30fc\u30ac\u30f3\u5927\u7d71\u9818\u306e\u4e3b\u6cbb\u533b\u3067\u3042\u3063\u305fRosenberg\u304c\u3001\u764c\u60a3\u8005\u306e\u30ea\u30f3\u30d1\u7403\uff08\u767d\u8840\u7403\u306e\u4e00\u7a2e\uff09\u3092\u8840\u6db2\u304b\u3089\u53d6\u308a\u51fa\u3057\u3001\u4f53\u5916\u3067\u57f9\u990a\u30fb\u5897\u6b96\u30fb\u6d3b\u6027\u5316\u3057\u3066\u304b\u3089\u4f53\u5185\u306b\u623b\u3059LAK\uff08lymphokine-activated killer\uff09\u7642\u6cd5\u3092\u958b\u767a\u3057\u3001\u5168\u4e16\u754c\u304c\u816b\u760d\u514d\u75ab\u5b66\u306b\u6ce8\u76ee\u3057\u59cb\u3081\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3053\u308c\u307e\u3067\u306e\u514d\u75ab\u7642\u6cd5\u306f\u3001\u4f53\u5185\u306e\u514d\u75ab\u80fd\u3092\u5168\u4f53\u7684\u306b\uff08\u975e\u7279\u7570\u7684\u306b\uff09\u6d3b\u6027\u5316\u3055\u305b\u308b\u3082\u306e\u3067\u3001\u764c\u7d30\u80de\u306b\u96c6\u4e2d\u3057\u305f\uff08\u7279\u7570\u7684\u306a\uff09\u514d\u75ab\u80fd\u3092\u8ce6\u6d3b\u3059\u308b\u8a33\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n

 <\/p>\n

\u764c\u30ef\u30af\u30c1\u30f3\u7642\u6cd5\u306e\u958b\u767a<\/h1>\n

\u305d\u3057\u30661991\u5e74\u3001\u30d9\u30eb\u30ae\u30fc\u306eBoon\u3089\u304c\u764c\u7d30\u80de\u306e\u307f\u306b\u73fe\u308c\u308b\u77ed\u3044\u86cb\u767d\uff08\u30da\u30d7\u30c1\u30c9\uff09\u3067\u3042\u308b\u764c\u6297\u539f\u306e\u30a2\u30df\u30ce\u9178\u914d\u5217\u3092\u5831\u544a\u3057\uff08van der Bruggen, Science, 1991\uff09\u3001\u764c\u7279\u7570\u7684\u514d\u75ab\u5fdc\u7b54\u306e\u8a98\u5c0e\u3001\u3059\u306a\u308f\u3061\u764c\u30ef\u30af\u30c1\u30f3\u306e\u958b\u767a\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u3092\u5951\u6a5f\u306b\u5168\u4e16\u754c\u3067\u591a\u304f\u306e\u764c\u6297\u539f\u304c\u767a\u898b\u3055\u308c\u3001\u307e\u305f\u305d\u306e\u764c\u6297\u539f\u30da\u30d7\u30c1\u30c9\u3092\u60a3\u8005\u306b\u6295\u4e0e\u3059\u308b\u81e8\u5e8a\u8a66\u9a13\u304c\u6570\u591a\u304f\u5b9f\u65bd\u3055\u308c\u307e\u3057\u305f\u3002\u5f53\u79d1\u306e\u8fd1\u677e\u6559\u6388\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u7d30\u80de\u306e\u764c\u5316\u3067\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3059p53\u86cb\u767d\u306b\u5bfe\u3059\u308b\u764c\u30ef\u30af\u30c1\u30f3\u7642\u6cd5\u306e\u958b\u767a\u306b\u5f53\u521d\u3088\u308a\u53d6\u308a\u7d44\u307f\uff08Chikamatsu, Clin Cancer Res, 1999; Eura, Clin Cancer Res, 2000; Chikamatsu, Cancer Res, 2003; Sakakura, Clin Immunol, 2007; Chikamatsu, Cancer Immunol Immunother, 2009\uff09\u3001\u73fe\u5728\u3067\u3082\u764c\u30ef\u30af\u30c1\u30f3\u958b\u767a\u306e\u7814\u7a76\u306f\u5f53\u7814\u7a76\u5ba4\u3067\u8108\u3005\u3068\u7d99\u7d9a\u3057\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n

 <\/p>\n

\u764c\u30ef\u30af\u30c1\u30f3\u7642\u6cd5\u306e\u9650\u754c<\/h1>\n

\u52d5\u7269\u5b9f\u9a13\u3042\u308b\u3044\u306f\u8a66\u9a13\u7ba1\u5185\u3067\u306f\u975e\u5e38\u306b\u826f\u597d\u306a\u6210\u7e3e\u304c\u5831\u544a\u3055\u308c\u305f\u764c\u6297\u539f\u30da\u30d7\u30c1\u30c9\u30ef\u30af\u30c1\u30f3\u3067\u3059\u304c\u3001\u3044\u3056\u764c\u60a3\u8005\u306b\u5bfe\u3059\u308b\u81e8\u5e8a\u8a66\u9a13\u3092\u884c\u3063\u3066\u307f\u308b\u3068\u3001\u305d\u306e\u6709\u52b9\u7387\u306f\u9a5a\u304f\u307b\u3069\u307f\u3058\u3081\u306a\u3082\u306e\u3067\u3057\u305f\uff08\u6709\u52b9\u73872.6%; Rosenberg, Nat Med, 2004\uff09\u3002\u764c\u60a3\u8005\u306b\u304a\u3044\u3066\u764c\u30ef\u30af\u30c1\u30f3\u306e\u6709\u52b9\u6027\u304c\u4f4e\u3044\u539f\u56e0\u306b\u3064\u3044\u3066\u591a\u304f\u306e\u8003\u5bdf\u304c\u306a\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u5927\u304d\u306a\u539f\u56e0\u306f2\u3064\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u4e00\u3064\u306f\u764c\u60a3\u8005\u81ea\u8eab\u306e\u514d\u75ab\u80fd\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3053\u3068\u3001\u3082\u3046\u4e00\u3064\u306f\u764c\u7d30\u80de\u81ea\u4f53\u304c\u60a3\u8005\u4f53\u5185\u306e\u514d\u75ab\u76e3\u8996\u30b7\u30b9\u30c6\u30e0\u304b\u3089\u9003\u308c\u3088\u3046\u3068\u3059\u308b\u3053\u3068\u3067\u3059\u3002\u73fe\u5728\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u514d\u75ab\u7cfb\u306b\u4e0d\u5229\u306a\u72b6\u6cc1\u304c\u764c\u60a3\u8005\u3067\u306a\u305c\u8d77\u3053\u308b\u304b\u3092\u89e3\u660e\u3057\u3001\u305d\u308c\u3092\u514b\u670d\u3059\u308b\u305f\u3081\u306e\u7814\u7a76\u304c\u4e3b\u4f53\u3068\u306a\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u3053\u306e\uff12\u3064\u306e\u554f\u984c\u70b9\u306b\u3064\u3044\u3066\u3001\u6211\u3005\u306e\u7814\u7a76\u6210\u679c\u3068\u5171\u306b\u8aac\u660e\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n

\uff08\uff11\uff09\u764c\u60a3\u8005\u306e\u514d\u75ab\u80fd\u4f4e\u4e0b<\/h4>\n

\u7279\u306b\u982d\u9838\u90e8\u764c\u60a3\u8005\u306e\u514d\u75ab\u6291\u5236\u72b6\u614b\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\u306f\u3001\u5f53\u79d1\u8fd1\u677e\u6559\u6388\u3084\u5742\u5009\u52a9\u6559\u306e\u7559\u5b66\u5148\u3067\u3042\u308b\u3001\u30d4\u30c3\u30c4\u30d0\u30fc\u30b0\u5927\u5b66\u764c\u7814\u7a76\u6240\u306eT. L. Whiteside\u6559\u6388\u306e\u30b0\u30eb\u30fc\u30d7\u304c\u4e2d\u5fc3\u7684\u306b\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002\u764c\u60a3\u8005\u3067\u306f\u8840\u4e2d\u306e\u30ea\u30f3\u30d1\u7403\u6570\u304c\u6e1b\u5c11\u3057\u3001\u30ea\u30f3\u30d1\u7403\u304c\u6b7b\u306b\u3084\u3059\u304f\u306a\u308a\u307e\u3059\uff08Kuss, Clin Cancer Res, 2004; Hoffmann Clin Cancer Res, 2002, Gastmann Cancer Res, 1999\uff09\u3002\u307e\u305f\u764c\u6297\u539f\u306e\u60c5\u5831\u3092\u30ea\u30f3\u30d1\u7403\u306b\u63d0\u793a\u3059\u308b\u6a39\u72b6\u7d30\u80de\u304c\u3001\u764c\u60a3\u8005\u306e\u30ea\u30f3\u30d1\u7bc0\uff08Sakakura, Oral Oncol, 2005\uff09\u3084\u8840\u6db2\u4e2d\uff08Sakakura, Cancer Immunol Immunother, 2006\uff09\u3067\u6e1b\u5c11\u3057\u305f\u308a\u6d3b\u6027\u304c\u4f4e\u4e0b\u3057\u305f\u308a\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u3001\u5f53\u30b0\u30eb\u30fc\u30d7\u306f\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3055\u3089\u306b\u764c\u60a3\u8005\u3067\u306f\u514d\u75ab\u7cfb\u3092\u6291\u5236\u3059\u308b\u6a5f\u80fd\u3092\u6301\u3064\u514d\u75ab\u62c5\u5f53\u7d30\u80de\u304c\u5897\u52a0\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u4e00\u3064\u304c\u4eac\u90fd\u5927\u5b66\u306e\u5742\u53e3\u5fd7\u6587\u6559\u6388\u306b\u3088\u3063\u3066\u767a\u898b\u3055\u308c\u305f\u8abf\u7bc0\u6027T\u7d30\u80de\uff08Treg\uff09\u3067\u3001\u982d\u9838\u90e8\u764c\u60a3\u8005\u3067\u3082\u8abf\u7bc0\u6027T\u7d30\u80de\u304c\u672b\u68a2\u8840\u304a\u3088\u3073\u816b\u760d\u5c40\u6240\u3067\u5897\u6b96\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08Sakakura, Cancer Immunol Immunother, 2006; Chikamatsu, Head neck,2007; Bergmann, Clin Cancer Res, 2008\uff09\u3002\u3082\u3046\u4e00\u3064\u306e\u514d\u75ab\u6291\u5236\u7d30\u80de\u3068\u3057\u3066\u3001\u9aa8\u9ac4\u7531\u6765\u514d\u75ab\u6291\u5236\u7d30\u80de\uff08MDSC\uff09\u304c\u6319\u3052\u3089\u308c\u3001\u3053\u306eMDSC\u3082\u982d\u9838\u90e8\u764c\u764c\u60a3\u8005\u306e\u8840\u6db2\u4e2d\u3067\u5897\u52a0\u3057\u3066\u3001\u764c\u60a3\u8005\u306e\u514d\u75ab\u80fd\u3092\u4f4e\u4e0b\u3055\u305b\u307e\u3059\uff08Pak, Clin Cancer Res, 1995; Chikamatsu, Cancer Sci, 2012\uff09\u3002<\/p>\n

\uff082\uff09\u60a3\u8005\u514d\u75ab\u76e3\u8996\u30b7\u30b9\u30c6\u30e0\u304b\u3089\u306e\u764c\u7d30\u80de\u306e\u9003\u907f\u3068\u764c\u5e79\u7d30\u80de\uff08cancer stem cell\uff09<\/h4>\n

\u982d\u9838\u90e8\u764c\u7d30\u80de\u306f\u305d\u308c\u81ea\u8eab\u304c\u3001\u514d\u75ab\u3092\u6291\u5236\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068\u547c\u3070\u308c\u308b\u6db2\u6027\u56e0\u5b50\u3092\u7523\u751f\u3057\u307e\u3059\u3002\u982d\u9838\u90e8\u764c\u7d30\u80de\u306fIL-10\u30fbTGF-beta\u30fbPGE2\u3068\u3044\u3046\u514d\u75ab\u6291\u5236\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u5206\u6ccc\u3057\u3066\u3001\u816b\u760d\u3078\u306e\u30ea\u30f3\u30d1\u7403\u6d78\u6f64\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08Young, Int J Cancer, 1996\uff09\u3002\u307e\u305f\u764c\u7d30\u80de\u306f\u305d\u306e\u764c\u6297\u539f\u3092\u3001HLA\u5206\u5b50\u306e\u4e0a\u306b\u4e57\u305b\u308b\u3053\u3068\u306b\u3088\u308a\u514d\u75ab\u7d30\u80de\u306b\u8a8d\u8b58\u3055\u308c\u307e\u3059\u3002\u5f53\u79d1\u5742\u5009\u52a9\u6559\u306e\u7559\u5b66\u5148\u3067\u3042\u308b\u30d4\u30c3\u30c4\u30d0\u30fc\u30b0\u5927\u5b66\u764c\u7814\u7a76\u6240\u306eS. Ferrone\u306e\u30b0\u30eb\u30fc\u30d7\uff08\u73fe\u5728\u306f\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66\uff09\u306f\u3001\u982d\u9838\u90e8\u764c\u7d30\u80de\u304c\u3053\u306eHLA\u5206\u5b50\u306e\u767a\u73fe\u3092\u4f4e\u4e0b\uff5e\u6d88\u5931\u3055\u305b\u3066\u3001\u60a3\u8005\u306e\u514d\u75ab\u76e3\u8996\u30b7\u30b9\u30c6\u30e0\u304b\u3089\u9003\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u3001\u305d\u308c\u304c\u4e88\u5f8c\u306b\u3082\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\uff08Ogino, Clin Cancer Res, 2003; Meissner, Clin Cancer Res, 2005; Ogino, Cancer Res, 2006; Lopez-Albaotero, J Immunol, 2006\uff09\u3002<\/p>\n

\u8fd1\u5e74\u306e\u764c\u7814\u7a76\u306b\u304a\u3051\u308b\u4e00\u3064\u306e\u5927\u304d\u306a\u30c8\u30d4\u30c3\u30af\u30b9\u306b\u3001\u764c\u5e79\u7d30\u80de\uff08cancer stem cell\uff09\u3068\u3044\u3046\u764c\u7d44\u7e54\u3092\u5f62\u6210\u3059\u308b\u5143\u3068\u306a\u308b\u5897\u6b96\u80fd\u306e\u9ad8\u3044\u7d30\u80de\u7fa4\u306e\u5b58\u5728\u304c\u3042\u308a\uff08Al-Haji, Proc Natl Acad Sci U S A, 2003\uff09\u3001\u3053\u306e\u7d30\u80de\u306f\u6297\u764c\u5264\u306a\u3069\u306e\u6cbb\u7642\u306b\u62b5\u6297\u6027\u304c\u3042\u308a\u307e\u3059\uff08Levina, PLoS One, 2008\uff09\u3002\u982d\u9838\u90e8\u764c\u306b\u304a\u3044\u3066\u3082\u3053\u306e\u764c\u5e79\u7d30\u80de\u306e\u5b58\u5728\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u304c\uff08Prince, Proc Natl Acad Sci U S A, 2007; Zhou, Laryngoscope, 2007; Chen Biochem Biophys Res Commun, 2009\uff09\u3001\u5f53\u79d1\u8fd1\u677e\u6559\u6388\u306f\u5f53\u521d\u304b\u3089\u3053\u306e\u7d30\u80de\u306b\u6ce8\u76ee\u3057\u3001\u305d\u306e\u5897\u6b96\u6cd5\u3084\u6027\u8cea\u3001\u3055\u3089\u306b\u306f\u305d\u306e\u514d\u75ab\u5b66\u7684\u7279\u6027\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\uff08Okamoto, Oral Oncol, 2009; Chikamatsu, Head Neck, 2011; Chikamatsu, Head Neck, 2012\uff09\u3002\u982d\u9838\u90e8\u764c\u306b\u304a\u3051\u308b\u764c\u5e79\u7d30\u80de\u306f\u6297\u539f\u63d0\u793a\u306b\u95a2\u308f\u308b\u5206\u5b50\u3092\u4f4e\u4e0b\u3055\u305b\u3001TGF-\uf062\u7b49\u306e\u514d\u75ab\u6291\u5236\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u5206\u6ccc\u3057\u30ea\u30f3\u30d1\u7403\u306e\u5897\u6b96\u3092\u6291\u5236\u3057\u3001\u3055\u3089\u306b\u8abf\u7bc0\u6027T\u7d30\u80de\u3084\u9aa8\u9ac4\u7531\u6765\u514d\u75ab\u6291\u5236\u7d30\u80de\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n

 <\/p>\n

\u4eca\u5f8c\u306e\u5c55\u671b<\/h1>\n

\u5f53\u79d1\u3067\u306f\u3088\u308a\u52b9\u679c\u7684\u306a\u764c\u7279\u7570\u7684\u514d\u75ab\u7642\u6cd5\u306e\u958b\u767a\u306b\u5411\u3051\u3066\u3001\u3088\u308a\u591a\u89d2\u7684\u3001\u5b66\u969b\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u764c\u30ef\u30af\u30c1\u30f3\u7642\u6cd5\u306e\u7814\u7a76\u3092\u7d9a\u3051\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u306f\u524d\u8ff0\u306e\u901a\u308a\u3001\u764c\u60a3\u8005\u306b\u304a\u3051\u308b\u514d\u75ab\u6291\u5236\u3084\u764c\u7d30\u80de\u306e\u514d\u75ab\u9003\u907f\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u304c\u3001\u6700\u7d42\u7684\u306b\u306f\u52b9\u679c\u7684\u306a\u514d\u75ab\u7642\u6cd5\u306e\u958b\u767a\u306b\u6709\u7528\u3068\u306a\u308b\u305f\u3081\u3001\u8fd1\u5e74\u306f\u816b\u760d\u5fae\u5c0f\u74b0\u5883\uff08tumor microenvironment\uff09\u306b\u304a\u3051\u308b\u764c\u7d30\u80de\u3068\u514d\u75ab\u7d30\u80de\u3084\u5468\u56f2\u306e\u7d30\u80de\u3068\u306e\u95a2\u4fc2\u306e\u89e3\u660e\u306b\u5411\u3051\u305f\u7814\u7a76\u3092\u884c\u3063\u3066\u304a\u308a\u307e\u3059\uff08Sakakura, Cancer Sci, 2014\uff09\u3002\u7686\u69d8\u306e\u4e00\u5c64\u306e\u3054\u7406\u89e3\u3068\u3054\u5354\u529b\u3092\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n

\u306a\u304a\u5f53\u5206\u91ce\u306b\u3064\u3044\u3066\u3088\u308a\u8a73\u3057\u3044\u60c5\u5831\u3092\u304a\u6c42\u3081\u306e\u65b9\u306f\u5f53\u79d1\u8fd1\u677e\u6559\u6388\u3068\u5742\u5009\u52a9\u6559\u306b\u3088\u308b\u4ee5\u4e0b\u306ereview\u3092\u662f\u975e\u3054\u89a7\u4e0b\u3055\u3044\u3002<\/p>\n

Sakakura K, Chikamatsu K. Immune suppression and evasion in patients with head and neck cancer. Advances in Cellular and Molecular Otolaryngology 2013, 1: 21809<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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